In a review published on April 5, researchers argue that modification to mRNA causes immune suppression that may contribute to cancer development.
The mRNA used in the COVID-19 vaccines has been modified from its naturally occurring form to prevent degradation by the immune system when injected. In a review published on April 5, researchers argue that modification – specifically, N1-methyl-pseudouridine modification – to mRNA causes immune suppression that may contribute to cancer development.
Uridine is a key component of mRNA. However, when mRNA is injected into the body, it is broken down by cells and also triggers a broad immune response, leading to its rapid degradation. This immune response can be bypassed: researchers Katalinko Kariko, Ph.D., and Dr. Drew Weissman found that when uridine is modified to N1-methyl-pseudouridine (m1-psi), the mRNA is not degraded and proteins can be produced. The two were awarded a 2023 Nobel award for their findings. Continue reading